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Prolotherapy/Regenerative Injection Therapy
Regenerative Injection Therapy (RIT), also known as Prolotherapy, is an innovative field of Regenerative Medicine consisting of therapies that naturally stimulate the body to self-heal. Prolotherapy or RIT is performed to stimulate repair of weakened, injured or painful joints. During Prolotherapy, a series of injections is administered into problem areas to initiate the reparative healing response known as the healing cascade.
Ozone Prolotherapy (Prolozone)
Ozone Therapy has perhaps the broadest clinical use of any healing modality known. Ozone Prolotherapy combines the healing properties of ozone with the technique and benefits of Prolotherapy. The healing properties unique to ozone’s three oxygen atom structure, are its ability to improve the body’s utilization of oxygen, thereby upregulating energy production, healing, and repair. Additionally, both Prolotherapy and ozone promote the activation of growth factors. Ozone Prolotherapy is especially beneficial for musculoskeletal pain, osteoarthritis (cartilage degeneration) and a variety of low back pain syndromes. This is because ozone optimizes healing, in part by removing inflammatory and degradation compounds from the joints. In this way, ozone even possesses analgesic properties, helping treated areas become pain-free more quickly.
Ozone Prolotherapy is researched to be therapeutic for spinal stenosis, low back pain, disc herniations, radiculopathies, knee pain, arthritis, ligament and tendon injuries, nerve pain and other conditions. Ozone can safely be injected into joints, ligaments, tendons and muscles. Ozone Prolotherapy is compatible with both dextrose Prolotherapy and Platelet-rich Plasma (PRP) Prolotherapy.
Platelet-rich Plasma (PRP) Prolotherapy
Trigger Point Injections
Regenerative Injection Therapy or Prolotherapy treats any form of musculoskeletal pain including osteoarthritis, sprains and strains, minor tears, repetitive use injuries, and those sustained by athletes. Treatments help new injuries or older ones that never healed properly.
- Ligament and tendon tears
- Back pain
- Groin pain
- Joint laxity and hypermobility
- Tennis elbow, golfer’s elbow
- Pain and arthritis of the neck
- Knee pain
- Sacroiliac pain/dysfunction
- Neck pain
- Rotator cuff injuries
- Pain at ischial tuberosity
- Shoulder pain
What is Prolotherapy?
Prolotherapy, also known as Regenerative Injection Therapy, is a non-surgical, in-office procedure that helps restore function and heal from painful and injured joints. Prolotherapy addresses the site of injury, along with the surrounding structures. Prolotherapy owes its name to proliferation as treatments cause the proliferation of healing cells that repair connective tissue. These healing cells release collagen and matrix to repair stretched and torn ligaments, tendons and cartilage. A variety of formulas may be used in Prolotherapy and include dextrose and procaine alone or in combination with bio-cellular agents such as Platelet-rich Plasma and stem cells. No matter the formula used, injections of tendons and ligaments to stimulate healing and repair is Prolotherapy.
A Better Model for Understanding Chronic Pain
Why Choose Prolotherapy
How Prolotherapy Works
Research spanning decades has found that the body responds to Prolotherapy just as with any injury; that is by stimulation of the wound healing cascade. This is your healing biology in action. The healing cascade begins with the release of messenger cells, signals and growth factors characteristic of the inflammatory response. Collectively, these signals recruit and send special cells called fibroblasts to the treated area. On arrival fibroblasts secrete collagen and matrix. This new collagen becomes incorporated into the injured ligaments and tendons to repair and strengthen them over time. Ultimately, the structural integrity of the joint is restored, function returns, and painful nerves stop firing.
Wound Healing Cascade
The best way to understand how and why Prolotherapy works is to be aware of the basics of wound healing. After a trauma, injury or surgery, the healing cascade is initiated to heal the wound. The wound healing cascade follows through distinct, sequential and partially overlapping stages. Prolotherapy works by simply exploiting the wound healing cascade.
|Wound Healing Cascade
|Inflammatory Phase: Characterized by swelling, pain and warmth. The Injured tissue is exposed to proinflammatory substances and growth factors secreted by macrophages and platelets respectively.
|Onset of injury
|about 4 days
|Proliferation Phase: The foundation of new tissue and blood vessel formation. Healing cells, most notably fibroblasts, produce collagen for wound repair.
|72 hours after injury
|about 4 weeks
|Remodeling Phase: Characterized by ongoing tissue regeneration and remodeling. Here collagen health and deposition continue as the wound’s strength and elasticity progresses.
The work and concepts developed by Dr. Hackett and others, along with the relationship between ligament and tendon dysfunction and chronic pain have now been well validated by research and case studies over the past few decades. Several post graduate training programs hold academic and hands-on conferences around the world for doctors wanting to learn Prolotherapy. Prolotherapy is now practiced by thousands of physicians who want to see their patients experience healing from chronic pain.